JAFFA: High sensitivity transcriptome-focused fusion gene detection
Details
Publication Year 2015,Volume 7,Issue #1,Page 43
Journal Title
Genome Med
Publication Type
Journal Article
Abstract
Genomic instability is a hallmark of cancer and, as such, structural alterations and fusion genes are common events in the cancer landscape. RNA sequencing (RNA-Seq) is a powerful method for profiling cancers, but current methods for identifying fusion genes are optimised for short reads. JAFFA (https://github.com/Oshlack/JAFFA/wiki) is a sensitive fusion detection method that outperforms other methods with reads of 100 bp or greater. JAFFA compares a cancer transcriptome to the reference transcriptome, rather than the genome, where the cancer transcriptome is inferred using long reads directly or by de novo assembling short reads.
Publisher
BioMed Central
WEHI Research Division(s)
Cancer And Haematology
PubMed ID
26019724
Open Access at Publisher's Site
http://www.genomemedicine/content/7/1/43
NHMRC Grants
NHMRC/1016647NHMRC/575581
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2015-06-15 09:53:25
Last Modified: 2016-04-20 11:08:20
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