JAFFA: High sensitivity transcriptome-focused fusion gene detection
- Author(s)
- Davidson, NM; Majewski, IJ; Oshlack, A;
- Details
- Publication Year 2015,Volume 7,Issue #1,Page 43
- Journal Title
- Genome Med
- Publication Type
- Journal Article
- Abstract
- Genomic instability is a hallmark of cancer and, as such, structural alterations and fusion genes are common events in the cancer landscape. RNA sequencing (RNA-Seq) is a powerful method for profiling cancers, but current methods for identifying fusion genes are optimised for short reads. JAFFA (https://github.com/Oshlack/JAFFA/wiki) is a sensitive fusion detection method that outperforms other methods with reads of 100 bp or greater. JAFFA compares a cancer transcriptome to the reference transcriptome, rather than the genome, where the cancer transcriptome is inferred using long reads directly or by de novo assembling short reads.
- Publisher
- BioMed Central
- Research Division(s)
- Cancer And Haematology
- PubMed ID
- 26019724
- Publisher's Version
- https://doi.org/10.1186/s13073-015-0167-x
- Open Access at Publisher's Site
http://www.genomemedicine/content/7/1/43- NHMRC Grants
- NHMRC/1016647, NHMRC/575581,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-06-15 09:53:25
Last Modified: 2016-04-20 11:08:20