Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis

Croker, BA; Silke, J; Gerlic, M

Author(s): Croker, BA; Silke, J; Gerlic, M;
Details: Publication Year 2015-07,Volume 22,Issue #4,Page 293-301
Journal Title: Curr Opin Hematol
Publication Type: Journal Article
Abstract: PURPOSE OF REVIEW: A feature of the innate immune response that is conserved across kingdoms is the induction of cell death. In this review, we discuss the direct and indirect effects of increased inflammatory cell death, including pyroptosis - a caspase-1-dependent cell death - and necroptosis - a receptor-interacting protein kinase 3/mixed lineage kinase domain-like protein-dependent, caspase-independent cell death - on emergency hematopoiesis. RECENT FINDINGS: Activation of nonapoptotic cell death pathways during infection can trigger release of cytokines and/or damage-associated molecular patterns such as interleukin (IL)-1alpha, IL-1beta, IL-18, IL-33, high-mobility group protein B1, and mitochondrial DNA to promote emergency hematopoiesis. During systemic infection, pyroptosis and necroptosis can directly kill hematopoietic stem and progenitor cells, which results in impaired hematopoiesis, cytopenia, and immunosuppression. Although originally described as discrete entities, there now appear to be more intimate connections between the nonapoptotic and death receptor signaling pathways. SUMMARY: The choice to undergo pyroptotic and necroptotic cell death constitutes a rapid response system serving to eliminate infected cells, including hematopoietic stem and progenitor cells. This system has the potential to be detrimental to emergency hematopoiesis during severe infection. We discuss the potential of pharmacological intervention for the pyroptosis and necroptosis pathways that may be beneficial during periods of infection and emergency hematopoiesis.
Publisher: Wolters Kluwer Health
Research Division(s): Cell Signalling And Cell Death
PubMed ID: 26049749
Publisher's Version: https://doi.org/10.1097/MOH.0000000000000148
NHMRC Grants: NHMRC/541901,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2015-06-22 12:12:31

Last Modified: 2016-02-18 11:31:11