Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
- Author(s)
- Teo, A; Hasang, W; Randall, LM; Unger, HW; Siba, PM; Mueller, I; Brown, GV; Rogerson, SJ;
- Details
- Publication Year 2015,Volume 14,Issue #1,Page 215
- Journal Title
- Malaria Journal
- Publication Type
- Journal Article
- Abstract
- BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION: Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS: NCT01136850.
- Publisher
- BioMed Central
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 26006260
- Publisher's Version
- https://doi.org/10.1186/s12936-015-0736-x
- Open Access at Publisher's Site
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Creation Date: 2015-06-15 09:53:30
Last Modified: 2019-04-01 09:10:59