Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer
- Author(s)
- Johnstone, CN; Chand, A; Putoczki, TL; Ernst, M;
- Journal Title
- Cytokine Growth Factor Rev
- Publication Type
- Journal Article
- Abstract
- Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology. Through the activation of the GP130-Janus kinase signaling cascade and associated transcription factor STAT3, IL-11 can confer many of the tumor intrinsic 'hallmark' capabilities to neoplastic cells, if they express the ligand-specific IL-11Ralpha receptor subunit. Accordingly, IL-11 signaling has recently been identified as a rate-limiting step for the growth tumors arising from the mucosa of the gastrointestinal tract. However, there is less appreciation for a potential role of IL-11 to support breast cancer progression, apart from its well documented capacity to facilitate bone metastasis. Here we review evidence that IL-11 expression in breast cancer correlates with poor disease outcome and discuss some of the molecular mechanisms that are likely to underpin these observations. These include the capacity of IL-11 to stimulate survival and proliferation of cancer cells alongside angiogenesis of the primary tumor and of metastatic progenies at distant organs. We review current strategies to interfere with IL-11 signaling and advocate that inhibition of IL-11 signaling may represent an emerging therapeutic opportunity for numerous cancers.
- Publisher
- Elsevier
- Research Division(s)
- Inflammation
- PubMed ID
- 26209885
- Publisher's Version
- https://doi.org/10.1016/j.cytogfr.2015.07.015
- Open Access at Publisher's Site
www.sciencedirect.com/science/article/pii/S1359610115000635- NHMRC Grants
- NHMRC/1008614, NHMRC/1080498, NHMRC/603122, NHMRC/1069024, NHMRC/1079257,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-07-28 12:00:07
Last Modified: 2015-08-18 02:55:30