PATTERNS OF CELLULAR DIFFERENTIATION IN SPONTANEOUS AND TRANSPLANTED LYMPHOMATA IN MICE.
- Author(s)
- Metcalf, D; Nakamura, K; Wiadrowski, M;
- Journal Title
- The Australian journal of experimental biology and medical science
- Publication Type
- Journal Article
- Abstract
- A cytological survey was made of thymic lymphoma tissue in AKR, (AKRxC3H)F1 and C3H mice with advanced spontaneous lymphoid leukaemia. In all strains, lyniphoma tissue contained a higher percentage of primitive lymphoid cells (large and medium lymphoma cells) than in the corresponding normal thymus. As a group, C3H and (AKRx C3H)F1 lymphomata were more highly differentiated than AKR lymphomata. Lymphomata in individual mice showed wide variations in the percentage distribution of the three types of lymphoma cells, but in any one animal the pattern of differentiation was the same in the thymus and lymph node lymphoma tissues. First generation thigh transplants of lymphoma tissue in AKR mice maintained the differentiation pattern of the original AKR thymic lymphoma tissue. It is concluded that in individual mice with lymphoid leukaemia a constant pattern of differentiation of the lymphoma tissue is maintained for the major portion of the duration of the disease.
- PubMed ID
- 14343502
- Publisher's Version
- https://doi.org/10.1038/icb.1965.75
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-07-23 08:59:28
Last Modified: 2015-07-23 03:53:25