Induction of bone marrow colony-stimulating activity by a filterable agent in leukemic and normal mouse serum.
- Author(s)
- Foster, R; Metcalf, D; Kirchmyer, R;
- Details
- Publication Year 1968-05-01,Volume 127,Issue #5,Page 853-66
- Journal Title
- The Journal of experimental medicine
- Publication Type
- Journal Article
- Abstract
- 1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.
- PubMed ID
- 5655100
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138494/
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-07-23 08:59:26
Last Modified: 2015-07-27 03:12:00