Factors modifying stem cell proliferation of myelomonocytic leukemic cells in vitro and in vivo.
- Author(s)
- Metcalf, D; Moore, MA;
- Details
- Publication Year 1970-04,Volume 44,Issue #4,Page 801-8
- Journal Title
- Journal of the National Cancer Institute
- Publication Type
- Journal Article
- Abstract
- Some cells of the transplantable myelomonocytic leukemia (WEHI-3) in BALB/c mice can proliferate in agar, and form mixed colonies of granulocytes and monocytes. These colony-forming cells were shown to be self-replicating and can be considered as leukemic stem cells. Individual in vitro colonies were implanted in the spleen or under the kidney capsule to produce progressively growing tumors with the same morphology as the original WEHI-3 tumor. Spleen tumors contained larger numbers of stem cells than kidney tumors. Frequency of stem cells was also high in tumors arising from colonies implanted into subcutaneous spleen grafts but not in tumors in subcutaneous thymus grafts. The rate of generation of stem cells in this myelomonocytic leukemic population appears in part to be a phenotypic property of the population and to be stimulated by the spleen micro-environment.
- PubMed ID
- 11515047
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- Refer to copyright notice on published article.
Creation Date: 2015-07-23 08:59:25
Last Modified: 2015-10-29 11:53:34