Spleen graft mast cell population changes following splenectomy of the host.
- Author(s)
- Metcalf, D;
- Details
- Publication Year 1965-08,Volume 43,Issue #4,Page 533-46
- Journal Title
- The Australian journal of experimental biology and medical science
- Publication Type
- Journal Article
- Abstract
- One-day-old C57B1 spleens grafted to splenectomised C57B1 and (AKR times C57B1)F1 recipients grew to a three times larger size, but contained fifteen to twenty times fewer mast cells than comparable grafts in sham operated recipients. Splenectomy of mice bearing established Spleen grafts led to a similar increase in graft size and fall in mast cell content. These effects of splnectomy were observed with both subcutaneous und kidney sub-capsular spleen grafs. Confirmatory results were obtained with AKR and C3H spleen grafts in isologous and F1 hybrid splenectomised and sham operated recipients. Treatment of splenectomised mice with spleen extracts or spleen tissue in dif fusion chambers did not change the number of spleen graft mast cells. Splenec-tomy had no effect on the mast cell content of other host tissues, or on the mast cell content of thymus grafts. Splenectomy before pregnancy had no effect on mast cell development in the fix-till spleen.
- PubMed ID
- 5861837
- Publisher's Version
- https://doi.org/10.1038/icb.1965.39
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-07-23 08:59:28
Last Modified: 2015-07-23 03:51:38