IRF4 activity is required in established plasma cells to regulate gene transcription and mitochondrial homeostasis
Details
Publication Year 2019-11-26, Volume 29, Issue #9, Page 2634-2645 e5
Journal Title
Cell Reports
Publication Type
Journal Article
Abstract
The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. The mechanism by which IRF4 exerts its action in mature plasma cells has been elusive due to the death of all such cells upon IRF4 loss. While we identify apoptosis as a critical pathway for the death of plasma cells caused by IRF4 loss, we also determine that IRF4 did not regulate the intrinsic apoptotic pathway directly. By using an inducible IRF4 deletion system in the presence of the overexpression of anti-apoptotic BCL2, we identify genes whose expression is coordinated by IRF4 and that in turn specify plasma cell identity and mitochondrial homeostasis.
Publisher
Elsevier
WEHI Research Division(s)
Immunology; Bioinformatics; Blood Cells And Blood Cancer
PubMed ID
31775034
Open Access at Publisher's Site
https://doi.org/10.1016/j.celrep.2019.10.097
NHMRC Grants
NHMRC/1054925
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-12-05 01:26:20
Last Modified: 2020-02-11 09:01:48
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