A class of gammadelta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Details
Publication Year 2019-12-20, Volume 366, Issue #6472, Page 1522-1527
Journal Title
Science
Publication Type
Journal Article
Abstract
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human gammadelta T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a gammadeltaTCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the gammadeltaTCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 alpha3 domain. A similar pattern of reactivity was observed for diverse MR1-restricted gammadeltaTCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human gammadelta T cells and redefine the parameters for TCR recognition.
Publisher
AAAS
WEHI Research Division(s)
Advanced Technology And Biology
PubMed ID
31857486
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-12-23 11:50:09
Last Modified: 2019-12-23 11:57:56
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