A class of gammadelta T cell receptors recognize the underside of the antigen-presenting molecule MR1
- Le Nours, J; Gherardin, NA; Ramarathinam, SH; Awad, W; Wiede, F; Gully, BS; Khandokar, Y; Praveena, T; Wubben, JM; Sandow, JJ; Webb, AI; von Borstel, A; Rice, MT; Redmond, SJ; Seneviratna, R; Sandoval-Romero, ML; Li, S; Souter, MNT; Eckle, SBG; Corbett, AJ; Reid, HH; Liu, L; Fairlie, DP; Giles, EM; Westall, GP; Tothill, RW; Davey, MS; Berry, R; Tiganis, T; McCluskey, J; Pellicci, DG; Purcell, AW; Uldrich, AP; Godfrey, DI; Rossjohn, J;
Publication Year 2019-12-20, Volume 366, Issue #6472, Page 1522-1527
- Journal Title
- Publication Type
- Journal Article
- T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human gammadelta T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a gammadeltaTCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the gammadeltaTCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 alpha3 domain. A similar pattern of reactivity was observed for diverse MR1-restricted gammadeltaTCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human gammadelta T cells and redefine the parameters for TCR recognition.
- WEHI Research Division(s)
- Advanced Technology And Biology
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- Publisher's Version
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Creation Date: 2019-12-23 11:50:09Last Modified: 2019-12-23 11:57:56