A class of gammadelta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Details
Publication Year 2019-12-20,Volume 366,Issue #6472,Page 1522-1527
Journal Title
Science
Publication Type
Journal Article
Abstract
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human gammadelta T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a gammadeltaTCR-MR1-antigen complex starkly contrasts with all other TCR-MHC and TCR-MHC-I-like complex structures. Namely, the gammadeltaTCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 alpha3 domain. A similar pattern of reactivity was observed for diverse MR1-restricted gammadeltaTCRs from multiple individuals. Accordingly, we simultaneously report MR1 as a ligand for human gammadelta T cells and redefine the parameters for TCR recognition.
Publisher
AAAS
WEHI Research Division(s)
Advanced Technology And Biology
PubMed ID
31857486
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-12-23 11:50:09
Last Modified: 2019-12-23 11:57:56
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