NOD Signaling and Cell Death
Journal Title
Frontiers in Cell and Devevelopmental Biology
Publication Type
Journal Article
Abstract
Innate immune signaling and programmed cell death are intimately linked, and many signaling pathways can regulate and induce both, transcription of inflammatory mediators or autonomous cell death. The best-characterized examples for these dual outcomes are members of the TNF superfamily, the inflammasome receptors, and the toll-like receptors. Signaling via the intracellular peptidoglycan receptors NOD1 and NOD2, however, does not appear to follow this trend, despite involving signaling proteins, or proteins with domains that are linked to programmed cell death, such as RIP kinases, inhibitors of apoptosis (IAP) proteins or the CARD domains on NOD1/2. To better understand the connections between NOD signaling and cell death induction, we here review the latest findings on the molecular regulation of signaling downstream of the NOD receptors and explore the links between this immune signaling pathway and the regulation of cell death.
Publisher
Frontiers Media
Research Division(s)
Inflammation
PubMed ID
31632962
Open Access at Publisher's Site
https://doi.org/10.3389/fcell.2019.00208
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-10-28 12:05:02
Last Modified: 2019-10-30 09:33:32
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