The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)
- Author(s)
- Murphy, JM;
- Details
- Publication Year 2019-11-11,Volume 12,Issue #8,Page a036376. 31712266
- Journal Title
- Cold Spring Harbor Perspectives in Biology
- Publication Type
- Journal Article
- Abstract
- Whereas the apoptosis cell death pathway typically enables cells to undergo death in an immunologically silent manner, cell death by necroptosis induces cell lysis and release of cellular constituents known to elicit an immune response. Consequently, the origins of necroptosis likely originated in host defense against pathogens, although recently it has emerged that dysregulation of the pathway underlies many human pathologies. The past decade has seen a rapid advance in our understanding of the molecular mechanisms underlying necroptotic cell death, including the implication of the pseudokinase, mixed lineage kinase domain-like protein (MLKL), as the terminal effector in the pathway. Here, I review our current understanding of how MLKL is activated by the upstream receptor interacting protein kinase (RIPK)3, the proposed mechanism(s) by which MLKL kills cells, and recently described layers of regulation that tune MLKL's killing activity.
- Publisher
- CSH Press
- Research Division(s)
- Inflammation
- PubMed ID
- 31712266
- Publisher's Version
- https://doi.org/10.1101/cshperspect.a036376
- NHMRC Grants
- NHMRC/1105754, NHMRC/1124735, NHMRC/1124737,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-11-20 02:45:22
Last Modified: 2020-10-17 02:51:43