Emerging strategies in the initial management of locally advanced rectal cancer
Details
Publication Year 2019-09,Volume 15,Issue #25,Page 2955-2965
Journal Title
Future Oncol
Publication Type
Journal Article
Abstract
The initial management of locally advanced rectal cancer continues to evolve and formulating the ideal treatment plan remains challenging, with a multitude of emerging treatment strategies and either limited or inconsistent data to support these. The main objective of neoadjuvant treatment is to maximize disease control and minimize toxicity and impact on quality of life. Ultimately, the optimal approach needs to be personalized to the individual. In this Review, we discuss the various strategies currently used and being further investigated in the initial treatment of patients presenting with locally advanced rectal cancer. We describe the evidence behind the current standard of care recommendations and emerging new options, as well as potential biomarkers that may assist with further refining treatment selection.
Publisher
Future Science Group
Keywords
neoadjuvant therapy; rectal cancer; sequencing
Research Division(s)
Personalised Oncology
PubMed ID
31424262
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-01-21 11:05:24
Last Modified: 2020-02-10 05:00:33
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