Speculations on the evolution of humoral adaptive immunity
- Author(s)
- Horton, MB; Hawkins, ED; Heinzel, S; Hodgkin, PD;
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Journal epub ahead of print
- Abstract
- The protection of a multicellular organism from infection, at both a cell and humoral level has been a tremendous driver of gene selection and cellular response strategies. Here we focus on a critical event in the development of humoral immunity: The transition from principally innate responses, to a system of adaptive cell selection, with all the attendant mechanical problems that must be solved in order for it to work effectively. Here we review recent advances, but our major goal is to highlight that the development of adaptive immunity resulted from the adoption, reuse and repurposing of an ancient, autonomous cellular programme, that combines and exploits three titratable cellular fate timers. We illustrate how this common cell machinery recurs and appears throughout biology, and has been essential for the evolution of complex organisms, at many levels of scale.
- Publisher
- Wiley
- Research Division(s)
- Immunology
- PubMed ID
- 32133683
- Publisher's Version
- https://doi.org/10.1111/imcb.12323
- Open Access at Publisher's Site
https://doi.org/10.1111/imcb.12323- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-03-24 01:39:41
Last Modified: 2020-03-24 02:05:02