Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail
- Author(s)
- Shin, K; Lechtenberg, BC; Fujimoto, LM; Yao, Y; Bartra, SS; Plano, GV; Marassi, FM;
- Details
- Publication Year 2019-09,Volume 5,Issue #9,Page eaax5068
- Journal Title
- Science Advances
- Publication Type
- Journal Article
- Abstract
- Vitronectin (Vn) is a major component of blood that controls many processes central to human biology. It is a drug target and a key factor in cell and tissue engineering applications, but despite long-standing efforts, little is known about the molecular basis for its functions. Here, we define the domain organization of Vn, report the crystal structure of its carboxyl-terminal domain, and show that it harbors the binding site for the Yersinia pestis outer membrane protein Ail, which recruits Vn to the bacterial cell surface to evade human host defenses. Vn forms a single four-bladed beta/alpha-propeller that serves as a hub for multiple functions. The structure explains key features of native Vn and provides a blueprint for understanding and targeting this essential human protein.
- Publisher
- AAAS
- Research Division(s)
- Ubiquitin Signalling
- PubMed ID
- 31535027
- Link To PubMed Central Version
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739113/
- Publisher's Version
- https://doi.org/10.1126/sciadv.aax5068
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-01-21 11:05:27
Last Modified: 2020-02-10 05:17:30