Impact of tumor and immunological heterogeneity on the anti-cancer immune response
- Author(s)
- Shembrey, C; Huntington, ND; Hollande, F;
- Details
- Publication Year 2019-08-21,Volume 11,Issue #9,Page pii: E121
- Journal Title
- Cancers (Basel)
- Publication Type
- Journal Article
- Abstract
- Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malignancy has helped establish escape from immunosurveillance as a critical requirement for incipient metastases. Our improved understanding of the immune system's interactions with cancer cells has led to major therapeutic advances but has also unraveled a previously unsuspected level of complexity. This review will discuss the vast spatial and functional heterogeneity in the tumor-infiltrating immune system, with particular focus on natural killer (NK) cells, as well as the impact of tumor cell-specific factors, such as secretome composition, receptor-ligand repertoire, and neoantigen diversity, which can further drive immunological heterogeneity. We emphasize how tumor and immunological heterogeneity may undermine the efficacy of T-cell directed immunotherapies and explore the potential of NK cells to be harnessed to circumvent these limitations.
- Publisher
- MDPI
- Research Division(s)
- Immunology
- PubMed ID
- 31438563
- Publisher's Version
- https://doi.org/10.3390/cancers11091217
- Open Access at Publisher's Site
https://doi.org/10.3390/cancers11091217- NHMRC Grants
- NHMRC/1069024, NHMRC/1164081,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-02-11 09:42:30
Last Modified: 2020-02-11 09:43:36