An appraisal of natural products active against parasitic nematodes of animals
- Author(s)
- Garcia-Bustos, JF; Sleebs, BE; Gasser, RB;
- Details
- Publication Year 2019-06-17,Volume 12,Issue #1,Page 306
- Journal Title
- Parasites & Vectors
- Publication Type
- Journal Article
- Abstract
- Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against parasitic nematodes of animals or against the model nematode Caenorhabditis elegans have been analysed. Scientific articles published since 2010 and patents granted from 2000, both inclusive, have been included in this analysis. The results show a scarcity of novel chemical structures, a limited follow-up of compounds disclosed before 2010 and a bias towards the screening of plant products, almost to the exclusion of other sources, when microbial extracts have, historically, provided most starting points for anti-infective drugs. All plant products published in this period were previously known, alerting to the high re-discovery rates of a limited number of chemical classes from this source. The most promising compounds described in the literature reviewed here, namely the linear nemadectin-derivatives, are novel and of bacterial origin. Patented but otherwise unpublished spiroketal structures also appear as interesting scaffolds for future development. The patent literature confirmed that it is possible to patent derivatives of previously known products, making them valid starting points for translational research.
- Publisher
- BMC
- Research Division(s)
- Chemical Biology
- PubMed ID
- 31208455
- Publisher's Version
- https://doi.org/10.1186/s13071-019-3537-1
- Open Access at Publisher's Site
https://doi.org/10.1186/s13071-019-3537-1- NHMRC Grants
- NHMRC/1113712,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-06-20 10:18:08
Last Modified: 2019-08-13 01:09:25