TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORgammat axis
Journal Title
Journal of Experimental Medicine
Publication Type
Journal Article in press
Abstract
Interleukin (IL)-17-producing CD8(+) T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, in contrast to interferon (IFN)-gamma-producing effector CD8(+) T cells, are not clear. Here we demonstrate that the transcription factor TCF-1 (Tcf7) regulates CD8(+) T cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and RORgammat, in parallel with TCF-1-driven modulation of chromatin state. Ablation of TCF-1 resulted in enhanced Tc17 cell development and exposed a gene set signature to drive tissue repair and lipid metabolism, which was distinct from other CD8(+) T cell subsets. IL-17-producing CD8(+) T cells isolated from healthy humans were also distinct from CD8(+)IL-17(-) T cells and enriched in pathways driven by MAF and RORgammat Overall, our study reveals how TCF-1 exerts central control of T cell differentiation in the thymus by normally repressing Tc17 differentiation and promoting an effector fate outcome.
Publisher
Rockefeller University Press
WEHI Research Division(s)
Bioinformatics; Immunology; Personalised Oncology
PubMed ID
31142588
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-06-14 09:37:01
Last Modified: 2019-06-14 11:24:13
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