Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2

Pauleikhoff, D; Bonelli, R; Dubis, AM; Gunnemann, F; Rothaus, K; Charbel Issa, P; Heeren, TF; Peto, T; Clemons, TE; Chew, EY; Bird, AC; Sallo, FB; MacTel Study Group,

Author(s): Pauleikhoff, D; Bonelli, R; Dubis, AM; Gunnemann, F; Rothaus, K; Charbel Issa, P; Heeren, TF; Peto, T; Clemons, TE; Chew, EY; Bird, AC; Sallo, FB; MacTel Study Group,;
Details: Publication Year 2019-11,Volume 97,Issue #7,Page e998-e1005
Journal Title: Acta Ophthalmologica
Publication Type: Journal Article
Abstract: PURPOSE: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. METHODS: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. RESULTS: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4-8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm(2) (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. CONCLUSION: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.
Publisher: Wiley
Research Division(s): Population Health And Immunity
PubMed ID: 30968592
Publisher's Version: https://doi.org/10.1111/aos.14110
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2019-04-12 10:26:46

Last Modified: 2019-10-28 10:14:07