Complement in malaria immunity and vaccines
Journal Title
Immunological Reviews
Publication Type
Journal Article in press
Abstract
Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this has proven to be immensely challenging over the decades. One major hindrance is the incomplete understanding of specific immune responses that confer protection against disease and/or infection. While antibodies to play a crucial role in malaria immunity, the functional mechanisms of these antibodies remain unclear as most research has primarily focused on the direct inhibitory or neutralizing activity of antibodies. Recently, there is a growing body of evidence that antibodies can also mediate effector functions through activating the complement system against multiple developmental stages of the parasite life cycle. These antibody-complement interactions can have detrimental consequences to parasite function and viability, and have been significantly associated with protection against clinical malaria in naturally acquired immunity, and emerging findings suggest these mechanisms could contribute to vaccine-induced immunity. In order to develop highly efficacious vaccines, strategies are needed that prioritize the induction of antibodies with enhanced functional activity, including the ability to activate complement. Here we review the role of complement in acquired immunity to malaria, and provide insights into how this knowledge could be used to harness complement in malaria vaccine development.
WEHI Research Division(s)
Infectious Diseases And Immune Defence
PubMed ID
31556468
Publisher's Version
https://doi.org/10.1111/imr.12802
Open Access at Publisher's Site
https://doi.org/10.1111/imr.12802
NHMRC Grants
NHMRC/1077636 NHMRC/1092789 NHMRC/1141278
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-10-23 02:22:53
Last Modified: 2019-10-23 02:40:53
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