IgM in human immunity to Plasmodium falciparum malaria
Details
Publication Year 2019-09, Volume 5, Issue #9, Page eaax4489
Journal Title
Science Advances
Publication Type
Journal Article
Abstract
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity.
Publisher
AAAS
WEHI Research Division(s)
Population Health And Immunity
PubMed ID
31579826
Open Access at Publisher's Site
https://doi.org/10.1126/sciadv.aax4489
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2019-10-23 02:22:49
Last Modified: 2019-10-23 02:27:08
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