gammadelta T-cell responses during HIV infection and antiretroviral therapy
- Author(s)
- Juno, JA; Eriksson, EM;
- Details
- Publication Year 2019,Volume 8,Issue #7,Page e01069
- Journal Title
- Clinical & Translational Immunology
- Publication Type
- Journal Article
- Abstract
- HIV infection is associated with a rapid and sustained inversion of the Vdelta1:Vdelta2 T-cell ratio in peripheral blood. Studies of antiretroviral therapy (ART)-treated cohorts suggest that ART is insufficient to reconstitute either the frequency or function of the gammadelta T-cell subset. Recent advances are now beginning to shed light on the relationship between microbial translocation, chronic inflammation, immune ageing and gammadelta T-cell immunology. Here, we review the impact of acute, chronic untreated and treated HIV infection on circulating and mucosal gammadelta T-cell subsets and highlight novel approaches to harness gammadelta T cells as components of anti-HIV immunotherapy.
- Publisher
- Wiley
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 31321033
- Publisher's Version
- https://doi.org/10.1002/cti2.1069
- Open Access at Publisher's Site
https://doi.org/10.1002/cti2.1069- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2019-07-26 09:44:15
Last Modified: 2019-07-26 12:12:50