Influence of comorbidity of cerebrovascular disease and amyloid-beta on alzheimer&#39;s disease

Yassi, N; Hilal, S; Xia, Y; Lim, YY; Watson, R; Kuijf, H; Fowler, C; Yates, P; Maruff, P; Martins, R; Ames, D; Chen, C; Rowe, CC; Villemagne, VL; Salvado, O; Desmond, PM; Masters, CL

Influence of comorbidity of cerebrovascular disease and amyloid-beta on alzheimer's disease

Author(s): Yassi, N; Hilal, S; Xia, Y; Lim, YY; Watson, R; Kuijf, H; Fowler, C; Yates, P; Maruff, P; Martins, R; Ames, D; Chen, C; Rowe, CC; Villemagne, VL; Salvado, O; Desmond, PM; Masters, CL;
Details: Publication Year 2020,Volume 73,Issue #3,Page 897-907
Journal Title: Journal of Alzheimers Disease
Publication Type: Journal Article
Abstract: BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer's disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-beta (Abeta), and their comorbidity on cognitive decline, hippocampal atrophy, and Abeta deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: Two-hundred and eighteen participants underwent Abeta PET, MRI, and cognitive assessment at 18-month intervals for up to 90 months. Abeta status was determined on baseline PET. Participants were also classified as V+ on baseline MRI if they had>/=1 large cortical infarcts, subcortical infarcts, or cortical cerebral microinfarcts; or white matter hyperintensity volume greater than the 90th percentile of healthy controls. Linear mixed models were conducted comparing slopes of change in cognition, hippocampal volume, and Abeta load between the four resultant groups. RESULTS: Mean age at baseline was 74 years (range 59-96). One-hundred and fifteen participants were cognitively normal, 54 had mild cognitive impairment, and 49 had Alzheimer's disease. Compared to the Abeta-/V- group, the Abeta+/V- and Abeta+/V+ groups showed significantly faster cognitive decline and hippocampal atrophy over 90 months. V+ status was associated with greater cognitive decline (Cohen's d = 0.85, p < 0.001) and hippocampal atrophy (d = 2.05, p < 0.001) in the Abeta+ group but not in the Abeta- group. V+ status was not associated with Abeta accumulation in any group. CONCLUSION: Comorbidity of cerebrovascular disease and Abeta was associated with cognitive decline and neurodegeneration. Cerebrovascular disease was not associated with the rate of Abeta accumulation.
Publisher: IOS Press
Research Division(s): Population Health And Immunity
PubMed ID: 31884485
Publisher's Version: https://doi.org/10.3233/JAD-191028
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2020-05-04 09:07:08

Last Modified: 2020-05-04 09:50:38