The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication
- Author(s)
- Waters, R; Ndengane, M; Abrahams, MR; Diedrich, CR; Wilkinson, RJ; Coussens, AK;
- Details
- Publication Year 2020-02,Volume 15,Issue #2,Page 101-125
- Journal Title
- Future Virology
- Publication Type
- Journal Article
- Abstract
- Accelerated tuberculosis and AIDS progression seen in HIV-1 and Mycobacterium tuberculosis (Mtb)-coinfected individuals indicates the important interaction between these syndemic pathogens. The immunological interaction between HIV-1 and Mtb has been largely defined by how the virus exacerbates tuberculosis disease pathogenesis. Understanding of the mechanisms by which pre-existing or subsequent Mtb infection may favor the replication, persistence and progression of HIV, is less characterized. We present a rationale for the critical consideration of 'latent' Mtb infection in HIV-1 prevention and cure strategies. In support of this position, we review evidence of the effect of Mtb infection on HIV-1 acquisition, replication and persistence. We propose that 'latent' Mtb infection may have considerable impact on HIV-1 pathogenesis and the continuing HIV-1 epidemic in sub-Saharan Africa.
- Publisher
- Future Medicine
- Research Division(s)
- Infectious Diseases And Immune Defence
- PubMed ID
- 32273900
- Publisher's Version
- https://doi.org/10.2217/fvl-2019-0069
- Open Access at Publisher's Site
https://doi.org/10.2217/fvl-2019-0069- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-05-04 09:07:08
Last Modified: 2020-05-04 10:00:17