RIPK1 ubiquitination: Evidence, correlations and the undefined
- Author(s)
- Simpson, DS; Gabrielyan, A; Feltham, R;
- Journal Title
- Seminars in Cell and Develpmental Biology
- Publication Type
- Journal epub ahead of print
- Abstract
- Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in particular, Receptor Interacting Protein Kinase 1 (RIPK1), has gained interest due to the ability to function upstream of both NF-kappaB signaling and caspase-dependent and -independent cell death. RIPK1 is critical in determining cell fate downstream of cytokine signaling receptors such as the Tumour Necrosis Factor Receptor Super Family (TNFRSF) and the innate immune Toll-like receptors. Various studies have attempted to untangle how ubiquitination of RIPK1 dictates signaling outcomes; however, due to the complex nature of ubiquitin signaling it has been difficult to prove that ubiquitination of RIPK1 does in fact influence signaling outcomes. Therefore, we ask the question: What do we really know about RIPK1 ubiquitination, and, to what extent can we conclude that ubiquitination of RIPK1 impacts RIPK1-mediated signaling events?
- Publisher
- Elsevier
- Research Division(s)
- Inflammation; Ubiquitin Signalling
- PubMed ID
- 32980239
- Publisher's Version
- https://doi.org/10.1016/j.semcdb.2020.08.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-10-02 02:01:49
Last Modified: 2020-10-02 02:39:52