Downregulation of the GHRH/GH/IGF-1 axis in a mouse model of Borjeson-Forssman-Lehman Syndrome
- Author(s)
- McRae, HM; Eccles, S; Whitehead, L; Alexander, WS; Gecz, J; Thomas, T; Voss, AK;
- Details
- Publication Year 2020-09-29,Volume 147,Issue #21,Page dev187021
- Journal Title
- Development
- Abstract
- The Borjeson-Forssman-Lehmann syndrome (BFLS) is an intellectual disability and endocrine disorder caused by plant homeodomain finger 6 (PHF6) mutations. BFLS patients present with short stature. We report a mouse model of BFLS, in which deletion of Phf6 causes a proportional reduction in body size compared to control mice. Growth hormone (GH) levels were reduced in the absence of PHF6. Phf6 (-) (/Y) animals displayed a reduction in the expression of the genes encoding GH releasing hormone (GHRH) in the brain, GH in the pituitary gland and insulin-like growth factor-1 (IGF-1) in the liver. Phf6 deletion specifically in the nervous system caused a proportional growth defect, indicating neuroendocrine contribution to the phenotype. Loss of suppressor of cytokine signaling 2 (SOCS2), a negative regulator of growth hormone signaling partially rescued body size, supporting a reversible deficiency in GH signaling. These results demonstrate that PHF6 regulates the GHRH/GH/IGF-1 axis.
- Publisher
- COB
- Research Division(s)
- Epigenetics And Development; Advanced Technology And Biology; Blood Cells And Blood Cancer
- PubMed ID
- 32994169
- Publisher's Version
- https://doi.org/10.1242/dev.187021
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-10-02 02:01:48
Last Modified: 2021-10-21 09:51:15