Identification and characterization of the long non-coding RNA Gm13218 as a novel regulator of Gata3
- Author(s)
- Chan, WF; Coughlan, HD; Iannarella, N; Smyth, GK; Johanson, TM; Keenan, CR; Allan, RS;
- Details
- Publication Year 0021-03-01,Volume 99,Issue #3,Page 323-332 (epub Sep 24 2020)
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Journal Article
- Abstract
- The eukaryotic genome is three-dimensionally segregated into discrete globules of topologically associating domains (TADs), within which numerous cis-regulatory elements such as enhancers and promoters interact to regulate gene expression. In this study, we identify a T cell-specific sub-TAD containing the Gata3 locus, and reveal a previously uncharacterised long non-coding RNA (lncRNA) Gm13218 within a distant enhancer lying approximately 280 kilobases downstream of Gata3. Gm13218 expression is highly correlated with that of Gata3 during early immune system development and T helper 2 (TH 2) cell differentiation. Inhibition and overexpression of Gm13218 suggest that it may be involved in the establishment, but not the maintenance of Gata3 expression. Overall, we propose that Gm13218 is a novel regulator of Gata3 and may inform therapeutic strategies in diseases such allergy and lymphoma where Gata3 has a pathological role.
- Publisher
- Wiley
- Research Division(s)
- Bioinformatics; Immunology
- PubMed ID
- 32970351
- Publisher's Version
- https://doi.org/10.1111/imcb.12408
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-10-02 02:01:47
Last Modified: 2021-10-20 10:18:21