Comorbidity of cerebrovascular and alzheimer's disease in aging
- Author(s)
- Xia, Y; Yassi, N; Raniga, P; Bourgeat, P; Desmond, P; Doecke, J; Ames, D; Laws, SM; Fowler, C; Rainey-Smith, SR; Martins, R; Maruff, P; Villemagne, VL; Masters, CL; Rowe, CC; Fripp, J; Salvado, O; Aibl research group;
- Journal Title
- Journal of Alzheimers Disease
- Abstract
- BACKGROUND: Cerebrovascular disease often coexists with Alzheimer's disease (AD). While both diseases share common risk factors, their interrelationship remains unclear. Increasing the understanding of how cerebrovascular changes interact with AD is essential to develop therapeutic strategies and refine biomarkers for early diagnosis. OBJECTIVE: We investigate the prevalence and risk factors for the comorbidity of amyloid-beta (Abeta) and cerebrovascular disease in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, and further examine their cross-sectional association. METHODS: A total of 598 participants (422 cognitively normal, 89 with mild cognitive impairment, 87 with AD) underwent positron emission tomography and structural magnetic resonance imaging for assessment of Abeta deposition and cerebrovascular disease. Individuals were categorized based on the comorbidity status of Abeta and cerebrovascular disease (V) as Abeta-V-, Abeta-V+, Abeta+V-, or Abeta+V+. RESULTS: Advancing age was associated with greater likelihood of cerebrovascular disease, high Abeta load and their comorbidity. Apolipoprotein E varepsilon4 carriage was only associated with Abeta positivity. Greater total and regional WMH burden were observed in participants with AD. However, no association were observed between Abeta and WMH measures after stratification by clinical classification, suggesting that the observed association between AD and cerebrovascular disease was driven by the common risk factor of age. CONCLUSION: Our observations demonstrate common comorbid condition of Abeta and cerebrovascular disease in later life. While our study did not demonstrate a convincing cross-sectional association between Abeta and WMH burden, future longitudinal studies are required to further confirm this.
- Publisher
- IOS Press
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 32986666
- Publisher's Version
- https://doi.org/10.3233/JAD-200419
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-10-17 02:40:34
Last Modified: 2021-08-03 02:12:49