A biobank of colorectal cancer patient-derived xenografts
- Author(s)
- Abdirahman, SM; Christie, M; Preaudet, A; Burstroem, MCU; Mouradov, D; Lee, B; Sieber, OM; Putoczki, TL;
- Journal Title
- Cancers (Basel)
- Publication Type
- Journal Article
- Abstract
- Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly for late-stage disease. Patient-derived xenografts (PDXs) have emerged as an informative, renewable experimental resource to model CRC architecture and biology. Here, we describe the generation of a biobank of CRC PDXs from stage I to stage IV patients. We demonstrate that PDXs within our biobank recapitulate the histopathological and mutation features of the original patient tumor. In addition, we demonstrate the utility of this resource in pre-clinical chemotherapy and targeted treatment studies, highlighting the translational potential of PDX models in the identification of new therapies that will improve the overall survival of CRC patients.
- Publisher
- MDPI
- Research Division(s)
- Personalised Oncology
- PubMed ID
- 32825052
- Publisher's Version
- https://doi.org/10.3390/cancers12092340
- Open Access at Publisher's Site
https://doi.org/10.3390/cancers12092340- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-10-17 02:40:34
Last Modified: 2020-11-03 09:53:45