The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Ng, SS; de Labastida Rivera, F; Yan, J; Corvino, D; Das, I; Zhang, P; Kuns, R; Chauhan, SB; Hou, J; Li, XY; Frame, TCM; McEnroe, BA; Moore, E; Na, J; Engel, JA; Soon, MSF; Singh, B; Kueh, AJ; Herold, MJ; Montes de Oca, M; Singh, SS; Bunn, PT; Aguilera, AR; Casey, M; Braun, M; Ghazanfari, N; Wani, S; Wang, Y; Amante, FH; Edwards, CL; Haque, A; Dougall, WC; Singh, OP; Baxter, AG; Teng, MWL; Loukas, A; Daly, NL; Cloonan, N; Degli-Esposti, MA; Uzonna, J; Heath, WR; Bald, T; Tey, SK; Nakamura, K; Hill, GR; Kumar, R; Sundar, S; Smyth, MJ; Engwerda, CR

Author(s): Ng, SS; de Labastida Rivera, F; Yan, J; Corvino, D; Das, I; Zhang, P; Kuns, R; Chauhan, SB; Hou, J; Li, XY; Frame, TCM; McEnroe, BA; Moore, E; Na, J; Engel, JA; Soon, MSF; Singh, B; Kueh, AJ; Herold, MJ; Montes de Oca, M; Singh, SS; Bunn, PT; Aguilera, AR; Casey, M; Braun, M; Ghazanfari, N; Wani, S; Wang, Y; Amante, FH; Edwards, CL; Haque, A; Dougall, WC; Singh, OP; Baxter, AG; Teng, MWL; Loukas, A; Daly, NL; Cloonan, N; Degli-Esposti, MA; Uzonna, J; Heath, WR; Bald, T; Tey, SK; Nakamura, K; Hill, GR; Kumar, R; Sundar, S; Smyth, MJ; Engwerda, CR;
Details: Publication Year 2020-10,Volume 21,Issue #10,Page 1205-1218
Journal Title: Nature Immunology
Publication Type: Journal Article
Abstract: Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4(+) and CD8(+) T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria-two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8(+) T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4(+) T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses.
Publisher: NPG
Research Division(s): Blood Cells And Blood Cancer
PubMed ID: 32839608
Publisher's Version: https://doi.org/10.1038/s41590-020-0758-6
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2020-10-02 09:53:37

Last Modified: 2020-10-02 10:07:24