Display of native antigen on cDC1 that have spatial access to both T and B cells underlies efficient humoral vaccination
Details
Publication Year 2020-10-01, Volume 205, Issue #7, Page 1842-1856
Journal Title
Journal of Immunology
Publication Type
Journal Article
Abstract
Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination.
Publisher
ASI
WEHI Research Division(s)
Immunology
PubMed ID
32839238
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-10-02 09:53:39
Last Modified: 2020-10-02 10:17:21
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