Smchd1 is a maternal effect gene required for genomic imprinting
- Author(s)
- Wanigasuriya, I; Gouil, Q; Kinkel, SA; Tapia Del Fierro, A; Beck, T; Roper, EA; Breslin, K; Stringer, J; Hutt, K; Lee, HJ; Keniry, A; Ritchie, ME; Blewitt, ME;
- Journal Title
- Elife
- Publication Type
- Journal Article
- Abstract
- Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expression of ten genes in mice. We also found zygotic SMCHD1 had a dose-dependent effect on the imprinted expression of seven genes. Together, zygotic and maternal SMCHD1 regulate three classic imprinted clusters and eight other genes, including non-canonical imprinted genes. Interestingly, the loss of maternal SMCHD1 does not alter germline DNA methylation imprints pre-implantation or later in gestation. Instead, what appears to unite most imprinted genes sensitive to SMCHD1 is their reliance on polycomb-mediated methylation as germline or secondary imprints, therefore we propose that SMCHD1 acts downstream of polycomb imprints to mediate its function.
- Publisher
- eLife Sciences
- Research Division(s)
- Epigenetics And Development
- PubMed ID
- 33186096
- Publisher's Version
- https://doi.org/10.7554/eLife.55529
- Open Access at Publisher's Site
https://doi.org/10.7554/eLife.55529- Terms of Use/Rights Notice
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Creation Date: 2021-02-01 12:07:30
Last Modified: 2021-03-02 11:29:02