Clinical and psychological phenomenology of pain in autoinflammatory diseases

Mulazzani, E; Zolyniak, N; Noe, E; Mulazzani, M; Azad, SC; K&#252;mpfel, T; Kraft, E

Author(s): Mulazzani, E; Zolyniak, N; Noe, E; Mulazzani, M; Azad, SC; Kümpfel, T; Kraft, E;
Details: Publication Year 2020-12-18,Volume 4,Issue #1,Page 71
Journal Title: BMC Rheumatology
Publication Type: Journal Article
Abstract: BACKGROUND: Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psychological presentation of pain has been performed to date. METHODS: Twenty-one symptomatic patients with variants in the NLRP3-, MEFV- and TNFRSF1A gene and clinical signs suggestive of an AID were retrospectively included in this monocentric cross-sectional case-series study. Patients were examined and interviewed using the German pain questionnaire. The hospital anxiety and depression scale (HADS) was applied to screen patients for anxiety and depression. RESULTS: Twenty out of 21 AID patients (95%) reported pain at the time of examination. Mean current pain intensity in all AID patients comprised 3.6 ± 1.3 and mean maximum pain intensity was 7.0 ± 1.6 on a 11-point numeric ranging scale (NRS). In 15 patients (71%), pain was present for more than 60 months. Ten patients (48%) experienced recurrent attacks with asymptomatic intervals and 7 patients (33%) suffered from constant pain, while 4 patients (19%) experienced both. Nociceptive pain including musculoskeletal and visceral affection was the most prominent type of pain (n = 20; 95%). Pain symptoms were treated continuously with analgesic or co-analgesic drugs in 10 patients (48%). Five patients (24%) have been positively screened for concomitant depression or anxiety. CONCLUSIONS: Early and prompt diagnosis is necessary to provide multimodal pain treatment and to avoid the development of chronic pain in patients with AID.
Publisher: BMC
Keywords: Autoinflammatory diseases; Low penetrance variants; Pain;
Research Division(s): Immunology
PubMed ID: 33334368
Publisher's Version: https://doi.org/10.1186/s41927-020-00168-x
Open Access at Publisher's Site: https://doi.org/10.1186/s41927-020-00168-x
Terms of Use/Rights Notice: Refer to copyright notice on published article.
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Creation Date: 2021-02-01 12:08:35

Last Modified: 2021-03-03 09:00:59