Cellular and Molecular Mechanisms of CD8(+) T Cell Differentiation, Dysfunction and Exhaustion
- Author(s)
- Verdon, DJ; Mulazzani, M; Jenkins, MR;
- Details
- Publication Year 2020-10-05,Volume 21,Issue #19,Page 7357
- Journal Title
- International Journal of Molecular Science
- Publication Type
- Journal Article
- Abstract
- T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before becoming functionally and phenotypically "exhausted" in settings of chronic infection, autoimmunity and in cancer. Exhausted T cells progressively lose canonical effector functions, exhibit altered transcriptional networks and epigenetic signatures and gain constitutive expression of a broad coinhibitory receptor suite. This review outlines recent advances in our understanding of exhausted T cell biology and examines cellular and molecular mechanisms by which a state of dysfunction or exhaustion is established, and mechanisms by which exhausted T cells may still contribute to pathogen or tumour control. Further, this review describes our understanding of exhausted T cell heterogeneity and outlines the mechanisms by which checkpoint blockade differentially engages exhausted T cell subsets to overcome exhaustion and recover T cell function.
- Publisher
- MDPI
- Research Division(s)
- Immunology
- PubMed ID
- 33027962
- Publisher's Version
- https://doi.org/10.3390/ijms21197357
- Open Access at Publisher's Site
https://doi.org/10.3390/ijms21197357- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-11-02 04:55:19
Last Modified: 2020-11-03 09:35:29