High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite
- Korhonen, PK; Gasser, RB; Ma, G; Wang, T; Stroehlein, AJ; Young, ND; Ang, CS; Fernando, DD; Lu, HC; Taylor, S; Reynolds, SL; Mofiz, E; Najaraj, SH; Gowda, H; Madugundu, A; Renuse, S; HOLT, D; Pandey, A; Papenfuss, AT; Fischer, K;
Publication Year 2020-10, Volume 14, Issue #10, Page e0008720
- Journal Title
- PLoS Neglected Tropical Diseases
- Publication Type
- Journal Article
- The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
- WEHI Research Division(s)
- PubMed ID
- Publisher's Version
- Open Access at Publisher's Site
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-02-01 12:07:25Last Modified: 2021-03-02 11:09:43