High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite
Details
Publication Year 2020-10, Volume 14, Issue #10, Page e0008720
Journal Title
PLoS Neglected Tropical Diseases
Publication Type
Journal Article
Abstract
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
WEHI Research Division(s)
Bioinformatics
PubMed ID
33001992
Open Access at Publisher's Site
https://doi.org/10.1371/journal.pntd.0008720
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-02-01 12:07:25
Last Modified: 2021-03-02 11:09:43
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