Necroptotic movers and shakers: cell types, inflammatory drivers and diseases
Journal Title
Curr Opin Immunol
Publication Type
Journal Article
Abstract
The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its potential involvement in related conditions. Recent insights into the essential membrane damaging necroptotic pseudokinase effector, Mixed lineage kinase domain like (MLKL), have revealed a growing number of diverse MLKL functions that contribute to the inflammatory nature of necroptosis. Here we review distinct MLKL signalling roles and document the immunogenic molecules released by necroptosis. We discuss specific in vivo MLKL-driven responses, the activation of inflammasome complexes and innate lymphoid cells that have been documented to drive disease. Finally, we list necroptotic competent cell types and their involvement in MLKL-driven cell death-associated and inflammatory-associated conditions.
Publisher
eLife Sciences
WEHI Research Division(s)
Inflammation
PubMed ID
33160107
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-02-01 12:05:22
Last Modified: 2021-03-02 10:46:07
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