Understanding IGF-II action through insights into receptor binding and activation
- Author(s)
- Blyth, AJ; Kirk, NS; Forbes, BE;
- Details
- Publication Year 2020-10-12,Volume 9,Issue #10,Page 2276
- Journal Title
- Cells
- Publication Type
- Journal epub ahead of print
- Abstract
- The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development. IGF-II is also found to be overexpressed in several cancer types, promoting growth and survival. It is also unique in the IGF system as it acts through both IGF-1R and insulin receptor isoform A (IR-A). Despite this, IGF-II is the least investigated ligand of the IGF system. This review will explore recent developments in IGF-II research including a structure of IGF-II bound to IGF-1R determined using cryo-electron microscopy (cryoEM). Comparisons are made with the structures of insulin and IGF-I bound to their cognate receptors. Finally discussed are outstanding questions in the mechanism of action of IGF-II with the goal of developing antagonists of IGF action in cancer.
- Publisher
- MDPI
- Keywords
- Igf-1r; Igf-ii; Ir-a; insulin receptor; insulin-like growth factor; receptor activation; structural studies
- Research Division(s)
- Structural Biology
- PubMed ID
- 33053840
- Publisher's Version
- https://doi.org/10.3390/cells9102276
- Open Access at Publisher's Site
https://doi.org/10.3390/cells9102276- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-02-01 12:05:24
Last Modified: 2021-03-02 10:55:50