Transcriptional memory-like imprints and enhanced functional activity in gammadelta T cells following resolution of malaria infection
- Author(s)
- Kumarasingha, R; Ioannidis, LJ; Abeysekera, W; Studniberg, S; Wijesurendra, D; Mazhari, R; Poole, DP; Mueller, I; Schofield, L; Hansen, DS; Eriksson, EM;
- Journal Title
- Frontiers in Immunology
- Publication Type
- Journal Article
- Abstract
- gammadelta T cells play an essential role in the immune response to many pathogens, including Plasmodium. However, long-lasting effects of infection on the gammadelta T cell population still remain inadequately understood. This study focused on assessing molecular and functional changes that persist in the gammadelta T cell population following resolution of malaria infection. We investigated transcriptional changes and memory-like functional capacity of malaria pre-exposed gammadelta T cells using a Plasmodium chabaudi infection model. We show that multiple genes associated with effector function (chemokines, cytokines and cytotoxicity) and antigen-presentation were upregulated in P. chabaudi-exposed gammadelta T cells compared to gammadelta T cells from naive mice. This transcriptional profile was positively correlated with profiles observed in conventional memory CD8(+) T cells and was accompanied by enhanced reactivation upon secondary encounter with Plasmodium-infected red blood cells in vitro. Collectively our data demonstrate that Plasmodium exposure result in "memory-like imprints" in the gammadelta T cell population and also promotes gammadelta T cells that can support antigen-presentation during subsequent infections.
- Publisher
- Frontiers Media
- Research Division(s)
- Infectious Diseases And Immune Defence; Bioinformatics; Population Health And Immunity
- PubMed ID
- 33154754
- Publisher's Version
- https://doi.org/10.3389/fimmu.2020.582358
- Open Access at Publisher's Site
https://doi.org/10.3389/fimmu.2020.582358- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-02-01 12:05:23
Last Modified: 2021-03-02 10:58:50