Action plan for hit identification (APHID): KAT6A as a case study
Journal Title
Future Medicinal Chemistry
Publication Type
Journal epub ahead of print
Abstract
Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.
Publisher
Future Science
WEHI Research Division(s)
Epigenetics And Development
PubMed ID
32064938
Open Access at Publisher's Site
https://doi.org/110.4155/fmc-2019-0212
NHMRC Grants
NHMRC/1030704 NHMRC/1080146
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-05-04 11:46:59
Last Modified: 2020-05-04 02:32:42
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