Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
Details
Publication Year 2020-05, Volume 22, Issue #5, Page 546-558
Journal Title
Nature Cell Biology
Publication Type
Journal
Abstract
Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal macrophages that form a contiguous network between the luminal and basal layers of the epithelial tree throughout postnatal development. Ductal macrophages are long lived and constantly survey the epithelium through dendrite movement, revealed via advanced intravital imaging. Although initially originating from embryonic precursors, ductal macrophages derive from circulating monocytes as they expand during puberty. Moreover, they undergo proliferation in pregnancy to maintain complete coverage of the epithelium in lactation, when they are poised to phagocytose milk-producing cells post-lactation and facilitate remodelling. Interestingly, ductal macrophages strongly resemble mammary tumour macrophages and form a network that pervades the tumour. Thus, the mammary epithelium programs specialized resident macrophages in both physiological and tumorigenic contexts.
Publisher
NPG
WEHI Research Division(s)
Cancer Biology And Stem Cells; Bioinformatics
PubMed ID
32341550
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-05-04 10:30:31
Last Modified: 2020-07-09 09:05:37
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