Emerging roles for interleukin-18 in the gastrointestinal tumor microenvironment
- Author(s)
- Fung, KY; Nguyen, PM; Putoczki, TL;
- Journal Title
- Advances in Experimental Medicine and Biology
- Publication Type
- Journal Article
- Abstract
- Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its active form by caspase-1, although other contributors to precursor processing are emerging.Numerous studies have evaluated the role of IL-18 within the gastrointestinal tract using genetic or complementary pharmacological tools and have revealed multiple roles in tumorigenesis. Most striking among these are the divergent roles for IL-18 in colon and gastric cancers. Here, we review our current understanding of IL-18 biology and how this applies to colorectal and gastric cancers.
- Publisher
- Springer
- Research Division(s)
- Personalised Oncology
- PubMed ID
- 32060888
- Publisher's Version
- https://doi.org/10.1007/978-3-030-38315-2_5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-05-04 11:46:51
Last Modified: 2020-05-04 01:58:10