Opportunities and challenges in long-read sequencing data analysis
Details
Publication Year 2020-02-07, Volume 21, Issue #1, Page 30
Journal Title
Genome Biology
Publication Type
Journal Article
Abstract
Long-read technologies are overcoming early limitations in accuracy and throughput, broadening their application domains in genomics. Dedicated analysis tools that take into account the characteristics of long-read data are thus required, but the fast pace of development of such tools can be overwhelming. To assist in the design and analysis of long-read sequencing projects, we review the current landscape of available tools and present an online interactive database, long-read-tools.org, to facilitate their browsing. We further focus on the principles of error correction, base modification detection, and long-read transcriptomics analysis and highlight the challenges that remain.
Publisher
BMC
WEHI Research Division(s)
Epigenetics And Development
PubMed ID
32033565
Open Access at Publisher's Site
https://doi.org/10.1186/s13059-020-1935-5
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-05-04 11:13:32
Last Modified: 2020-05-04 11:14:09
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