The genetics of epilepsy
- Author(s)
- Perucca, P; Bahlo, M; Berkovic, SF;
- Journal Title
- Annual Review of Genomics and Humam Genetics
- Publication Type
- Journal epub ahead of print
- Abstract
- Epilepsy encompasses a group of heterogeneous brain diseases that affect more than 50 million people worldwide. Epilepsy may have discernible structural, infectious, metabolic, and immune etiologies; however, in most people with epilepsy, no obvious cause is identifiable. Based initially on family studies and later on advances in gene sequencing technologies and computational approaches, as well as the establishment of large collaborative initiatives, we now know that genetics plays a much greater role in epilepsy than was previously appreciated. Here, we review the progress in the field of epilepsy genetics and highlight molecular discoveries in the most important epilepsy groups, including those that have been long considered to have a nongenetic cause. We discuss where the field of epilepsy genetics is moving as it enters a new era in which the genetic architecture of common epilepsies is starting to be unraveled. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 21 is August 31, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
- Publisher
- Annual Reviews
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 32339036
- Publisher's Version
- https://doi.org/10.1146/annurev-genom-120219-074937
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-05-04 10:30:35
Last Modified: 2020-05-04 10:57:39