Siglec-10 expression is up-regulated in activated human CD4(+) T cells
- Author(s)
- Bandala-Sanchez, E; Bediaga, NG; Naselli, G; Neale, AM; Harrison, LC;
- Details
- Publication Year 2020-02-08,Volume 81,Issue #2-3,Page 101-104
- Journal Title
- Human Immunology
- Publication Type
- Journal Article
- Abstract
- Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we examined the expression of Siglec-10 at the RNA and protein level in human CD4(+) T cells. Analysis by RNAseq, qPCR and flow cytometry demonstrated that, in contrast to other Siglecs, after activation of CD4(+) T cells Siglec-10 was selectively upregulated in a subset of cells also high for CD52 expression. This observation is consistent with a homeostatic role for Siglec-10 in human CD4(+) T cells.
- Publisher
- Elsevier
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 32046870
- Publisher's Version
- https://doi.org/10.1016/j.humimm.2020.01.009
- NHMRC Grants
- NHMRC/1080887,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-05-04 11:46:48
Last Modified: 2020-05-04 01:45:49