Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity
Journal Title
Chemical Communications
Publication Type
Journal epub ahead of print
Abstract
An efficient and functional group tolerant route to access hydroxy 1,8-naphthalimides has been used to synthesise a range of mono- and disubstituted hydroxy-1,8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6 in vitro with tubulin acetylation assays confirming that these compounds are more effective than tubastatin.
Publisher
Royal Society of Chemistry
WEHI Research Division(s)
Chemical Biology
PubMed ID
32432616
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-05-25 01:55:00
Last Modified: 2020-05-25 02:06:24
An error has occurred. This application may no longer respond until reloaded. Reload 🗙