Inflammasomes and cell death: common pathways in microparticle diseases
- Author(s)
- Rashidi, M; Wicks, IP; Vince, JE;
- Journal Title
- Trends in Molecular Medicine
- Publication Type
- Journal epub ahead of print
- Abstract
- The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation. These particulate-driven diseases include joint, lung, kidney, cardiovascular, and neurodegenerative disorders. Recently a conserved proinflammatory inflammasome signaling pathway elicited by such microparticles has become apparent. Here, we review disease-promoting microparticles and the mechanisms by which they trigger activation of the inflammasome complexes responsible for generating bioactive interleukin-1beta (IL-1beta) and inducing cell death. We highlight how microparticle-induced inflammasome and cell death responses diverge from canonical inflammasome activators, and discuss the preclinical and clinical targeting of inflammasomes to treat microparticle-driven diseases.
- Publisher
- Cell Press
- Research Division(s)
- Inflammation
- PubMed ID
- 32646646
- Publisher's Version
- https://doi.org/10.1016/j.molmed.2020.06.005
- NHMRC Grants
- NHMRC/1145788, NHMRC/1101405, NHMRC/1141466,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-07-21 10:52:56
Last Modified: 2020-07-21 11:37:01