NOTCH your usual suspect: MYC charged with controlling neuroendocrine cell-fate in small cell lung cancer
- Author(s)
- Ng, J; Sutherland, KD;
- Details
- Publication Year 2020-07-13,Volume 38,Issue #1,Page 17-20
- Journal Title
- Cancer Cell
- Publication Type
- Journal Article
- Abstract
- Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.
- Publisher
- Cell Press
- Research Division(s)
- Cancer Biology And Stem Cells
- PubMed ID
- 32663464
- Publisher's Version
- https://doi.org/10.1016/j.ccell.2020.06.009
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-07-21 10:52:55
Last Modified: 2020-07-21 11:33:40