An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling version 1; peer review: 2 approved]
Author(s)
Han, J; Wu, J; Silke, J;
Journal Title
F1000Research
Publication Type
Journal Article
Abstract
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.
Publisher
F1000
WEHI Research Division(s)
Inflammation
PubMed ID
32612808
Open Access at Publisher's Site
https://doi.org/10.12688/f1000research.22092.1
NHMRC Grants
NHMRC/1107149
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-07-21 09:27:38
Last Modified: 2020-07-21 10:43:19
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