Decreased bioefficacy of long-lasting insecticidal nets and the resurgence of malaria in Papua New Guinea
- Author(s)
- Vinit, R; Timinao, L; Bubun, N; Katusele, M; Robinson, LJ; Kaman, P; Sakur, M; Makita, L; Reimer, L; Schofield, L; Pomat, W; Mueller, I; Laman, M; Freeman, T; Karl, S;
- Details
- Publication Year 2020-07-20,Volume 11,Issue #1,Page 3646
- Journal Title
- Nature Communications
- Publication Type
- Journal Article
- Abstract
- Papua New Guinea (PNG) has the highest malaria transmission outside of Africa. Long-lasting insecticidal nets (LLINs) are believed to have helped to reduce average malaria prevalence in PNG from 16% in 2008 to 1% in 2014. Since 2015 malaria in PNG has resurged significantly. Here, we present observations documenting decreased bioefficacy of unused LLINs with manufacturing dates between 2013 and 2019 collected from villages and LLIN distributors in PNG. Specifically, we show that of n = 167 tested LLINs manufactured after 2013, only 17% are fulfilling the required World Health Organisation bioefficacy standards of >/= 80% 24 h mortality or >/= 95% 60 min knockdown in bioassays with pyrethroid susceptible Anopheles farauti mosquitoes. In contrast, all (100%, n = 25) LLINs with manufacturing dates prior to 2013 are meeting these bioefficacy standards. These results suggest that decreased bioefficacy of LLINs is contributing to the malaria resurgence in PNG and increased scrutiny of LLIN quality is warranted.
- Publisher
- NPG
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 32686679
- Publisher's Version
- https://doi.org/10.1038/s41467-020-17456-2
- Open Access at Publisher's Site
https://doi.org/10.1038/s41467-020-17456-2- NHMRC Grants
- NHMRC/GNT1161627, NHMRC/GNT1141441,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-08-05 10:02:59
Last Modified: 2020-08-05 10:19:55