How IGF-II binds to the human type 1 insulin-like growth factor receptor
Journal Title
Structure
Publication Type
Journal epub ahead of print
Abstract
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like growth factor I. Here, we describe the cryoelectron microscopy structure of insulin-like growth factor II bound to a leucine-zipper-stabilized IGF-1R ectodomain, determined in two conformations to a maximum average resolution of 3.2 A. The two conformations differ in the relative separation of their respective points of membrane entry, and comparison with the structure of insulin-like growth factor I bound to IGF-1R reveals long-suspected differences in the way in which the critical C domain of the respective growth factors interact with IGF-1R.
Publisher
Cell Press
WEHI Research Division(s)
Structural Biology; Advanced Technology And Biology
PubMed ID
32459985
Open Access at Publisher's Site
https://doi.org/10.1016/j.str.2020.05.002
NHMRC Grants
NHMRC/1128553
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2020-06-03 09:37:48
Last Modified: 2020-06-03 09:55:04
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