How IGF-II binds to the human type 1 insulin-like growth factor receptor
- Author(s)
- Xu, Y; Kirk, NS; Venugopal, H; Margetts, MB; Croll, TI; Sandow, JJ; Webb, AI; Delaine, CA; Forbes, BE; Lawrence, MC;
- Journal Title
- Structure
- Publication Type
- Journal epub ahead of print
- Abstract
- Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like growth factor I. Here, we describe the cryoelectron microscopy structure of insulin-like growth factor II bound to a leucine-zipper-stabilized IGF-1R ectodomain, determined in two conformations to a maximum average resolution of 3.2 A. The two conformations differ in the relative separation of their respective points of membrane entry, and comparison with the structure of insulin-like growth factor I bound to IGF-1R reveals long-suspected differences in the way in which the critical C domain of the respective growth factors interact with IGF-1R.
- Publisher
- Cell Press
- Research Division(s)
- Structural Biology; Advanced Technology And Biology
- PubMed ID
- 32459985
- Publisher's Version
- https://doi.org/10.1016/j.str.2020.05.002
- Open Access at Publisher's Site
https://doi.org/10.1016/j.str.2020.05.002- NHMRC Grants
- NHMRC/1128553,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2020-06-03 09:37:48
Last Modified: 2020-06-03 09:55:04